Assessment of stability and compatibility of dermatophagoides and blomia allergen mixture for sublingual immunotherapy

Background House Dust Mites are important etiological agents of respiratory allergy. Allergen mixtures are often used for specific immunotherapy in polysensitized patients, although scientific evidence to support its efficacy, safety and stability is scarce. Sublingual immunotherapy (SLIT) is being gradually accepted as an alternative to conventional subcutaneous immunotherapy. For SLIT, higher allergen doses are recommended, so the development of pharmaceutical formulations allowing the administration of such high doses is particularly relevant. Therefore, the aim of this work was to develop and evaluate liquid formulations of allergenic extracts of house dust mites: Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomiatropicalis, containing glycerol, for administration as sublingual vaccine.